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The Role of GLP-1 in Weight Loss: A Simple Guide for Everyone

  • Writer: Stephanie Bailey
    Stephanie Bailey
  • 6 days ago
  • 4 min read

Silver digital scale with a measuring tape, logo of Mending Hearts Primary Care above, text says "Bringing Health and Wellness to Your Home."
Elevate your weight loss journey at Mending Hearts Primary Care

Are you struggling to find effective weight loss solutions?


You’re not alone; many people are actively seeking reliable ways to shed those stubborn pounds.



Among the numerous options available, GLP-1 injectable medications like Semaglutide, Tirzepatide, and Liraglutide have gained attention as effective tools in the fight for weight management.


✨A Closer Look at GLP-1 Medications


GLP-1 (glucagon-like peptide-1) medications help individuals lose weight by mimicking a hormone that regulates appetite and insulin production. Let’s explore some of the most notable GLP-1 medications and their mechanisms.


1. Semaglutide and Tirzepatide


Both Semaglutide and Tirzepatide are weekly injectable medications that act as GLP-1 receptor agonists, designed to reduce appetite, increase feelings of fullness and promote weight loss.


Benefits:

  • Both medications can lead to significant weight loss, typically between 15-20% of their body weight with Tirzepatide outperforming Semaglutide in some studies.

  • Both are particularly beneficial for blood sugar management in individuals with type 2 diabetes, leading to an average decrease in A1C levels by 1-2%.


  • When used in conjunction with diet and exercise, both can cause significant weight loss — and a reduced risk of diabetes and heart disease.


Side Effects:

  • Common side effects include nausea (experienced by up to 30% of users), diarrhea, constipation and vomiting.


  • Most people notice that these side effects improve as the body adjusts to the medication, usually within four to eight weeks. Beginning with a lower dose and gradually increasing it can help minimize side effects.


Who Should Consider It:

  • Adults with:

    • Body mass index (BMI) of 30 or greater.


    • BMI of 27 or greater and at least one weight-related condition, such as high blood pressure, Type 2 diabetes or high cholesterol.


Who Should Not Use It:

  • Adults with:

    • Family history or personal history of medullary thyroid cancer

    • History of gallbladder disease

    • History of pancreatitis

    • Multiple endocrine neoplasia syndrome type 2 (MEN2)

    • Current Pregnancy or plans to become pregnant


Gloved hand holds a syringe, injecting medicine into a person's abdomen.
The best place to inject GLP-1 medication is in the fatty layer under the skin, typically in the abdomen about two inches from the navel. It can also be injected in the upper arms and thighs.

2. Liraglutide


Liraglutide is a GLP-1 medication focused on weight management and diabetes control.


Benefits:

  • Provides gradual weight loss, typically around 5-10% of body weight over several months.


  • Effectively reduces appetite, making it easier to maintain a calorie deficit.


Side Effects:

  • Some users report side effects like nausea and occasional headaches.


Who Should Consider It:

  • Similar to Semaglutide, Liraglutide is intended for adults with a BMI of 30 or higher and is ideal for individuals who prefer daily injections and desire a consistent method for weight loss.


🌿Building Lasting Wellness Through Healthy Habits

While GLP-1 medications are effective for weight loss, they yield the best results when combined with healthy habits.


  • Healthy diet: 

    • A balanced nutritious diet in whole foods (fruits, vegetables, lean proteins, whole grains)

    • Meal planning and portion control

    • Staying Hydration


  • Regular Exercise: 

    • Finding enjoyable activities is key

    • 30 minutes cardiovascular exercise 3-4 times weekly (brisk walking, cycling, swimming)

    • Strength training (weights, resistance exercises)


    A bowl with grilled chicken, couscous, diced carrots, green vegetables, and a lemon slice on a wooden background. Vibrant healthy meal.
    Incorporating a balanced and nutritious diet into your daily routine is essential.

🌟Exploring Non-GLP-1 Weight Loss Solutions


While GLP-1 medications are helpful, they are not the only solutions available. Here are some alternatives worth considering:


  • Lifestyle Changes: A personalized diet and exercise plan can boost weight loss. For instance, eating more fruits, vegetables, and whole grains can increase your fiber intake while reducing processed foods can help lower caloric intake.


  • Behavioral Therapy: Participating in counseling or support groups can effectively address emotional eating and help you develop healthier habits, leading to sustainable weight management.


  • Other Medications: Various other weight loss medications can suit those who do not respond well to GLP-1s, such as Orlistat or Phentermine.


✨Choosing Mending Hearts Primary Care for Your Weight Loss Journey


When it comes to weight loss, a customized approach is essential. At Mending Hearts Primary Care, we prioritize personalized care. Our mobile services allow us to offer weight loss programs that cater specifically to you, ensuring each person receives the guidance they need.


Why Choose Us?


  • Convenience: Enjoy care in the comfort of your home or through telemedicine consultations, making it easier to fit medical support into your busy life.


  • Personalized Attention: Get a weight loss program tailored just for you, encompassing medications, diet, and exercise plans that suit your specific needs and lifestyle.


  • Ongoing Support: Through regular check-ins, we help monitor your progress and adjust your plan as needed, promoting continuous improvement.


📞 Call us at 813-278-1241 or visit us at


A doctor in a white coat smiles while talking to an older man in an office with large windows. A tablet is present for documentation.
Your healthcare provider can assist you in this decision-making process and help determine if a taking a GLP-1 for weight loss aligns with your health goals


Mending Hearts Primary Care flyer with nurse practitioner, contact info, and services in Hillsborough & Pinellas counties. Warm, inviting tone.
Serving Tampa, St. Petersburg, and all of Pinellas and Hillsborough County, our mobile primary care services are here to assist you.

References

Cleveland Clinic. (n.d.). GLP-1 agonists. Retrieved October 10, 2025, from https://my.clevelandclinic.org/health/treatments/13901-glp-1-agonists

National Center for Biotechnology Information. (2021). GLP-1 receptor agonists: A review of their use in diabetes management. In StatPearls. Retrieved October 10, 2025, fromhttps://www.ncbi.nlm.nih.gov/books/NBK551568/

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